Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere

• Published in: Journal of virology Vol. 90; no. 10; pp. 4864 - 4875
• Main Authors: Lazear, Helen M., Diamond, Michael S.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.05.2016
• Subjects: Aedes - virology; Animals; Dengue virus; Dengue Virus - immunology; Dengue Virus - physiology; Disease Outbreaks; Disease Reservoirs - virology; Female; Flavivirus; Global Health; Guillain-Barre Syndrome - etiology; Guillain-Barre Syndrome - virology; Humans; Infectious Disease Transmission, Vertical; Microcephaly - virology; Minireview; Mosquito Vectors - virology; Oceania - epidemiology; Pregnancy; Pregnancy Complications, Infectious - virology; Viral Vaccines; Zika virus; Zika Virus - genetics; Zika Virus - physiology; Zika Virus Infection - complications; Zika Virus Infection - epidemiology; Zika Virus Infection - transmission; Zika Virus Infection - virology
• ISSN: 0022-538X; 1098-5514; 1098-5514
• DOI: 10.1128/JVI.00252-16

Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern. In this review, we discuss the history and epidemiology of ZIKV infection, recent outbreaks in Oceania and the emergence of ZIKV in the Western Hemisphere, newly ascribed complications of ZIKV infection, including Guillain-Barré syndrome and microcephaly, potential interactions between ZIKV and dengue virus, and the prospects for the development of antiviral agents and vaccines.