Light selectively alters vasoactive intestinal peptide and peptide histidine isoleucine immunoreactivity within the rat suprachiasmatic nucleus

The concentration of vasoactive intestinal peptide (VIP)-, peptide histidine isoleucine (PHI)-, neurotensin (NT)- and substance P (SP)-like immunoreactivity (LI) within the suprachiasmatic nucleus (SCN) were determined by radioimmunoassay in rats housed in LD 14:10 h, constant light or constant dark...

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Bibliographic Details
Published inBrain research Vol. 437; no. 1; p. 189
Main Authors Albers, H E, Minamitani, N, Stopa, E, Ferris, C F
Format Journal Article
LanguageEnglish
Published Netherlands 22.12.1987
Subjects
Animals
Darkness
Light
Male
Osmolar Concentration
Peptide PHI - metabolism
Radioimmunoassay
Rats
Rats, Inbred Strains
Suprachiasmatic Nucleus - metabolism
Time Factors
Vasoactive Intestinal Peptide - metabolism
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Summary:The concentration of vasoactive intestinal peptide (VIP)-, peptide histidine isoleucine (PHI)-, neurotensin (NT)- and substance P (SP)-like immunoreactivity (LI) within the suprachiasmatic nucleus (SCN) were determined by radioimmunoassay in rats housed in LD 14:10 h, constant light or constant dark. No day-night differences were observed in the concentration of VIP-, PHI-, NT- or SP-LI within the SCN. Exposure to constant light significantly depressed the SCN concentrations of VIP- and PHI-LI, but had no significant effects on SCN concentrations of NT- or SP-LI, or VIP- or PHI-LI concentrations within the cortex. These data represent the first evidence that VIP/PHI-containing neurons may be involved in mediating photic information within the SCN.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(87)91544-7