Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) in the oral mucosa

• Published in: Indian journal of dental research Vol. 23; no. 2; pp. 271 - 274
• Main Authors: Aggarwal, Anshul, Keluskar, Vaishali
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.03.2012; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Adult; Angiolymphoid hyperplasia with an eosinophilia; Angiolymphoid Hyperplasia with Eosinophilia - diagnosis; Development and progression; Diagnosis, Differential; Endothelial Cells - pathology; Endothelium; Endothelium, Vascular - pathology; Eosinophilia; Eosinophils - pathology; epithelioid hemangioma; Female; Females; Follow-Up Studies; Hemangioma; Hemangioma - diagnosis; Humans; Hyperplasia; Insect bites; Lip Diseases - diagnosis; Lip Neoplasms - diagnosis; Lymphocytes; Lymphocytes - pathology; Medical diagnosis; Mouth Mucosa - pathology; oral mucosa; Pathogenesis
• ISSN: 0970-9290; 1998-3603
• DOI: 10.4103/0970-9290.100439

Angiolymphoid hyperplasia with an eosinophilia (ALHE) is a rare benign entity whose etiology and pathogenesis is under debate. Clinically, it is characterised by cutaneous papules or nodules on the head and neck. Literature reveals very few cases of this entity in the oral mucosa. Here, we report a case of ALHE in a 25 year-old woman, who presented with a painless, 5mm x 5mm, sub mucosal erythematous nodule on left angle of mouth at lower lip. Histological examination of lip biopsy specimens revealed an increase in small vessels. The vascular walls consist of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.