Obstructive sleep apnea treatment, slow wave activity, and amyloid‐β
Obstructive sleep apnea (OSA) increases risk of dementia, a relationship that may be mediated by amyloid‐β (Aβ) and downstream Alzheimer disease pathology. We previously showed that OSA may impair Aβ clearance and affect the relationship between slow wave activity (SWA) and Aβ. In this study, SWA an...
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Published in | Annals of neurology Vol. 85; no. 2; pp. 291 - 295 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken, USA
John Wiley & Sons, Inc
01.02.2019
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Obstructive sleep apnea (OSA) increases risk of dementia, a relationship that may be mediated by amyloid‐β (Aβ) and downstream Alzheimer disease pathology. We previously showed that OSA may impair Aβ clearance and affect the relationship between slow wave activity (SWA) and Aβ. In this study, SWA and CSF Aβ were measured in participants with OSA before and 1 to 4 months after treatment. OSA treatment increased SWA, and SWA was significantly correlated with lower Aβ after treatment. Greater improvement in OSA was associated with greater decreases in Aβ. We propose a model whereby OSA treatment may affect both Aβ release and clearance. Ann Neurol 2018 ANN NEUROL 2019;85:291–295. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author Contributions Conception and design of the study: YSJ, DMH. Acquisition and analysis of data: YSJ, MAZ, MBF, AMF. Drafting a significant portion of the manuscript: YSJ, DMH. All authors reviewed and approved the final version of the manuscript. |
ISSN: | 0364-5134 1531-8249 |
DOI: | 10.1002/ana.25408 |