miRNAs as short non-coding RNAs in regulating doxorubicin resistance

• Published in: Journal of cell communication and signaling Vol. 17; no. 4; pp. 1181 - 1202
• Main Authors: Mirzaei, Sepideh, Paskeh, Mahshid Deldar Abad, Moghadam, Farhad Adhami, Entezari, Maliheh, Koohpar, Zeinab Khazaei, Hejazi, Elahe Sadat, Rezaei, Shamin, kakavand, Amirabbas, Aboutalebi, Maryam, Zandieh, Mohammad Arad, Rajabi, Romina, Salimimoghadam, Shokooh, Taheriazam, Afshin, Hashemi, Mehrdad, Samarghandian, Saeed
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2023; John Wiley & Sons, Inc
• Subjects: Biomedical and Life Sciences; Biomedicine; Cancer chemotherapy; Cell Biology; Cell cycle; Cell death; Chemoresistance; Chemotherapy; Circular RNA; Cytoplasm; Cytotoxicity; DNA topoisomerase; Doxorubicin; Life Sciences; MicroRNA; MicroRNAs; miRNA; Nanoparticles; Non-coding RNA; P-Glycoprotein; Review; Tumor cells; Tumors; Ursolic acid; MicroRNA; Cancer chemotherapy; Doxorubicin; Non-coding RNA; Chemoresistance
• ISSN: 1873-9601; 1873-961X
• DOI: 10.1007/s12079-023-00789-0

The treatment of cancer patients has been prohibited by chemoresistance. Doxorubicin (DOX) is an anti-tumor compound disrupting proliferation and triggering cell cycle arrest via inhibiting activity of topoisomerase I and II. miRNAs are endogenous RNAs localized in cytoplasm to reduce gene level. Abnormal expression of miRNAs changes DOX cytotoxicity. Overexpression of tumor-promoting miRNAs induces DOX resistance, while tumor-suppressor miRNAs inhibit DOX resistance. The miRNA-mediated regulation of cell death and hallmarks of cancer can affect response to DOX chemotherapy in tumor cells. The transporters such as P-glycoprotein are regulated by miRNAs in DOX chemotherapy. Upstream mediators including lncRNAs and circRNAs target miRNAs in affecting capacity of DOX. The response to DOX chemotherapy can be facilitated after administration of agents that are mostly phytochemicals including curcumol, honokiol and ursolic acid. These agents can regulate miRNA expression increasing DOX’s cytotoxicity. Since delivery of DOX alone or in combination with other drugs and genes can cause synergistic impact, the nanoparticles have been introduced for drug sensitivity. Graphical abstract The non-coding RNAs determine the response of tumor cells to doxorubicin chemotherapy. microRNAs play a key role in this case and they can be sponged by lncRNAs and circRNAs, showing interaction among non-coding RNAs in the regulation of doxorubicin sensitivity.