Light‐Triggered Inactivation of Enzymes with Photothermal Nanoheaters

A universal method for inactivating enzymes on demand is introduced, which involves irradiating nanorod‐bound enzymes with near‐infrared light. The subsequent generation of plasmonic heat denatures the enzymes selectively without damaging other proteins or cell membranes present in the same solution...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 13; no. 15; pp. np - n/a
Main Authors Thompson, Sebastian A., Paterson, Sureyya, Azab, Marwa M. M., Wark, Alastair W., de la Rica, Roberto
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.04.2017
Subjects
Animals
CHO Cells
Cricetinae
Cricetulus
Damage
Demand
Enzyme Activation - radiation effects
Enzymes
glucose oxidase
Glucose Oxidase - metabolism
gold
horseradish peroxidase
Horseradish Peroxidase - metabolism
hyperthermia
Inactivation
Light
Membranes
nanorods
Nanostructure
Nanotechnology
Nanotubes - chemistry
Plasmonics
Proteins
Temperature
gold
hyperthermia
nanorods
glucose oxidase
horseradish peroxidase
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Summary:A universal method for inactivating enzymes on demand is introduced, which involves irradiating nanorod‐bound enzymes with near‐infrared light. The subsequent generation of plasmonic heat denatures the enzymes selectively without damaging other proteins or cell membranes present in the same solution.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201603195