Clinical Utility and Approach to Estimate Postprandial Hypertriglycemia by A Newly Designed Oral Fat-loading Test

• Published in: Journal of Atherosclerosis and Thrombosis Vol. 10; no. 5; pp. 314 - 320
• Main Authors: Igarashi, Masahiko, Hirata, Akihiko, Yamauchi, Toshiyuki, Yamaguchi, Hiroshi, Tsuchiya, Hiromi, Ohnuma, Hiroshi, Jimbu, Yumi, Okuyama, Yoko, Shirata, Toru, Otsu, Nobuhiro, Fukuyama, Haru, Takahashi, Sachiko, Tominaga, Makoto, Kato, Takeo
• Format: Journal Article
• Language: English
• Published: Japan Japan Atherosclerosis Society 2003
• Subjects: Adult; Apolipoproteins A - blood; Blood Glucose; C-Reactive Protein - metabolism; Cholesterol - blood; Cholesterol, HDL - blood; Dietary Fats - administration & dosage; Fat-loading test; Fatty Acids, Nonesterified - blood; Female; Humans; Hypertriglyceridemia - diagnosis; Insulin - blood; Lipoprotein(a) - blood; Lipoproteins - blood; Male; Postprandial Period; Reference Values; Telmeal; Triglycerides - blood; Triglycerides; Remnant-like particle-cholesterol
• ISSN: 1340-3478; 1880-3873
• DOI: 10.5551/jat.10.314

The objective of this study was to estimate postprandial hypertriglycemia by a newly designed oral fat-loading test. Twenty-three healthy normolipidemic volunteers were orally administered a test meal consisting of a mixture of Telmeal 2.0® and 20 g of salt-free butter after fasting for 12 h. To measure the levels of total cholesterol (T-Cho), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), remnant-like particle-cholesterol (RLP-C), lipoprotein (a) [Lp (a)], free fatty acid, apolipoproteins (Apos), plasma glucose (PG), immunoreactive insulin (IRI), and high-sensitivity C-reactive protein (hs-CRP), venous blood samples were collected before the meal and at each hour until 9 h after fat-loading. The levels of both TG and RLP-C were drastically elevated at 2 h after fat-loading and these levels remained high until 4 h (p < 0.01). A significant correlation between TG and RLP-C was also observed at 2, 3 and 4 h, and the values of the correlation coefficients (r) were 0.837, 0.838, and 0.908, respectively. In contrast, the levels of T-Cho, HDL-C, Lp (a), Apos, PG, and hs-CRP did not change. Furthermore, there were no gastrointestinal symptoms during or after the study. These results strongly suggested that this newly designed fat-loading test was very useful for evaluating postprandial hypertriglycemia, including remnant concentrations.