Detection of viral interleukin-6 in Kaposi sarcoma–associated herpesvirus–linked disorders

• Published in: Blood Vol. 97; no. 7; pp. 2173 - 2176
• Main Authors: Aoki, Yoshiyasu, Yarchoan, Robert, Wyvill, Kathleen, Okamoto, Shin-ichiro, Little, Richard F., Tosato, Giovanna
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.04.2001; The Americain Society of Hematology
• Subjects: Anti-HIV Agents - therapeutic use; Antibodies, Viral - blood; Biological and medical sciences; Blood Donors; Castleman Disease - blood; Castleman Disease - classification; Castleman Disease - epidemiology; Castleman Disease - pathology; Castleman Disease - virology; CD4-CD8 Ratio; Comorbidity; Enzyme-Linked Immunosorbent Assay; Herpesviridae Infections - blood; Herpesviridae Infections - complications; Herpesviridae Infections - epidemiology; Herpesviridae Infections - virology; Herpesvirus 8, Human - genetics; Herpesvirus 8, Human - immunology; Herpesvirus 8, Human - isolation & purification; Herpesvirus 8, Human - pathogenicity; Herpesvirus 8, Human - physiology; HIV Infections - blood; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Seronegativity; Human viral diseases; Humans; Immunoglobulin G - blood; Infectious diseases; Interleukin-6 - blood; Italy - epidemiology; Japan - epidemiology; Lymphoma, AIDS-Related - blood; Lymphoma, AIDS-Related - epidemiology; Lymphoma, AIDS-Related - virology; Medical sciences; Sarcoma, Kaposi - blood; Sarcoma, Kaposi - epidemiology; Sarcoma, Kaposi - virology; United States - epidemiology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Proteins - blood; Virus Replication; Human; Immunopathology; Skin disease; Pathogenesis; Herpesviridae; Cytokine; Retroviridae; AIDS; Malignant tumor; Immune deficiency; Lentivirus; Infection; Virus; Interleukin 6; Herpesvirus hominis 6; Kaposi sarcoma; Concomitant disease; Viral disease; Human immunodeficiency virus; Primary effusion lymphoma
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V97.7.2173

Expression of a viral interleukin-6 (vIL-6) has been detected in certain Kaposi sarcoma (KS)–associated herpesvirus positive (KSHV+) lesions. The release of vIL-6 systemically and its contribution to the pathogenesis of HIV-related malignancies was studied. Serum vIL-6 was detected in 13 (38.2%) of 34 HIV+ patients with KS, in 6 (85.7%) of 7 HIV+patients with primary effusion lymphoma (PEL) and/or multicentric Castleman disease (MCD), and in 18 (60.0%) of 30 HIV+, mostly homosexual, individuals without KS, MCD, or PEL. By contrast, serum vIL-6 was detected in only 3 (23.1%) of 13 patients with classic KS, 1 (2.5%) of 40 blood donors from the United States, and 4 (19.0%) of 21 blood donors from Italy. Circulating vIL-6 levels were associated with HIV+ status (P < .0001). However, within the HIV+ cohort, serum vIL-6 levels were not associated with the occurrence of KSHV-associated malignancies (P = .43).