Gentamicin Release Study in Uniaxial and Coaxial Polyhydroxybutyrate–Polyethylene Glycol–Gentamicin Microfibers Treated with Atmospheric Plasma

• Published in: Polymers Vol. 15; no. 19; p. 3889
• Main Authors: Transito-Medina, Josselyne, Vázquez-Vélez, Edna, Castillo, Marilú Chávez, Martínez, Horacio, Campillo, Bernardo
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 26.09.2023; MDPI
• Subjects: Aminoglycosides; Antibiotics; Bacterial infections; Biocompatibility; Contact angle; drug delivery; Drug delivery systems; electrospun fibers; Fourier transforms; Gentamicin; Health aspects; Microfibers; modification plasma; PHB-PEG; Plasma; Plasma physics; Polyethylene glycol; Polyhydroxybutyrate; Polymers; Polyvinyl alcohol; Product introduction; Raman spectroscopy; Skin; Software; Surfactants; Tissue engineering; Wound healing; Mexico; Germany
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym15193889

The skin is the largest organ and one of the most important in the human body, and is constantly exposed to pathogenic microorganisms that cause infections; then, pharmacological administration is required. One of the basic medical methods for treating chronic wounds is to use topical dressings with characteristics that promote wound healing. Fiber-based dressings mimic the local dermal extracellular matrix (ECM), maintaining an ideal wound-healing climate. This work proposes electrospun PHB/PEG polymeric microfibers as dressings for administering the antibiotic gentamicin directed at skin infections. PHB-PEG/gentamicin fibers were characterized before and after plasma treatment by Raman spectroscopy, FTIR, and XRD. SEM was used to evaluate fiber morphology and yarn size. The plasma treatment improved the hydrophilicity of the PHB/PEG/gentamicin fibers. The release of gentamicin in the plasma-treated fibers was more sustained over time than in the untreated ones.