Phytochemistry and pharmacology of natural prenylated flavonoids

Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain enriched the structural diversity of flavonoids and increased their bioactivity and bioavailability. Prenylated flavonoi...

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Published inArchives of pharmacal research Vol. 46; no. 4; pp. 207 - 272
Main Authors Lv, Hua-Wei, Wang, Qiao-Liang, Luo, Meng, Zhu, Meng-Di, Liang, Hui-Min, Li, Wen-Jing, Cai, Hai, Zhou, Zhong-Bo, Wang, Hong, Tong, Sheng-Qiang, Li, Xing-Nuo
Format Journal Article
LanguageEnglish
Published Seoul Pharmaceutical Society of Korea 01.04.2023
대한약학회
Subjects
Flavonoids - chemistry
Flavonoids - pharmacology
Medicine
Pharmacology/Toxicology
Pharmacy
Prenylation
Review
약학
Anti-cancer
Pharmacological activity
Anti-inflammatory
Phytochemistry
Prenylated flavonoid
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Summary:Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain enriched the structural diversity of flavonoids and increased their bioactivity and bioavailability. Prenylated flavonoids show a wide range of biological activities, such as anti-cancer, anti-inflammatory, neuroprotective, anti-diabetic, anti-obesity, cardioprotective effects, and anti-osteoclastogenic activities. In recent years, many compounds with significant activity have been discovered with the continuous excavation of the medicinal value of prenylated flavonoids, and have attracted the extensive attention of pharmacologists. This review summarizes recent progress on research into natural active prenylated flavonoids to promote new discoveries of their medicinal value.
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https://doi.org/10.1007/s12272-023-01443-4
ISSN:0253-6269
1976-3786
DOI:10.1007/s12272-023-01443-4