Chronic inflammation caused by lymphotoxin is lymphoid neogenesis

In presenting a unifying concept for chronic inflammation and lymphoid organogenesis, we suggest that lymphotoxin's (LT, LT-alpha, TNF-beta) crucial role in these processes is pivotal and similar. Chronic inflammatory lesions that developed in the kidney and pancreas at the sites of transgene e...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 183; no. 4; pp. 1461 - 1472
Main Authors Kratz, A, Campos-Neto, A, Hanson, M S, Ruddle, N H
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 01.04.1996
Subjects
Animals
Antigens, CD - analysis
Cell Movement
Chronic Disease
DNA-Binding Proteins
Flow Cytometry
Insulin - genetics
Islets of Langerhans - pathology
Kidney - pathology
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - physiology
Lymphoid Tissue - growth & development
Lymphotoxin-alpha - genetics
Lymphotoxin-alpha - metabolism
Mice
Mice, Mutant Strains
Mice, Transgenic
Nephritis - etiology
Nephritis - immunology
Pancreatitis - etiology
Pancreatitis - immunology
Promoter Regions, Genetic
Proteins - genetics
Proteins - metabolism
Recombinant Fusion Proteins - metabolism
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Summary:In presenting a unifying concept for chronic inflammation and lymphoid organogenesis, we suggest that lymphotoxin's (LT, LT-alpha, TNF-beta) crucial role in these processes is pivotal and similar. Chronic inflammatory lesions that developed in the kidney and pancreas at the sites of transgene expression in rat insulin promoter-LT (RIP-LT) mice resembled lymph nodes with regard to cellular composition (T cells, B cells, plasma cells, and antigen-presenting cells), delineated T and B cell areas, primary and secondary follicles, characteristic morphologic and antigenic (ICAM-1, VCAM-1, MAdCAM-1, and PNAd) features of high endothelial venules, and ability to respond to antigen and undergo Ig class switching when obtained from mice immunized with SRBC. The vascular changes, with the exception of PNAd, appear to be the direct consequence of transgene derived LT expression, as they were also observed in RIP-LT mice lacking mature T and B cells. These data show that LT-induced chronic inflammation has the characteristics of organized lymphoid tissue.
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ISSN:0022-1007
1540-9538
DOI:10.1084/jem.183.4.1461