One-pot synthesis and antibacterial activities of pyrazolo[4′,3′:5,6]pyrido[2,3- d]pyrimidine-dione derivatives

• Published in: Bioorganic & medicinal chemistry Vol. 18; no. 21; pp. 5800 - 5803
• Main Authors: Bazgir, Ayoob, Khanaposhtani, Maryam Mohammadi, Soorki, Ali Abolhasani
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.11.2008; Elsevier
• Subjects: 1 H-Pyrazol-5-amines; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Barbituric acid; Biological and medical sciences; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Medical sciences; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Pyrazolopyrimidine; Pyrimidines - chemical synthesis; Pyrimidines - pharmacology; Pyrimidopyrimidine; Thiobarbituric acid; 1 H-Pyrazol-5-amines; Barbituric acid; Pyrazolopyrimidine; Thiobarbituric acid; Pyrimidopyrimidine; Pseudomonadales; Escherichia coli; Bacillaceae; Staphylococcus; Pyrazolopyrimidine derivatives; Amine; Bacillales; Bacillus; Pyrazole derivatives; Bacteria; Micrococcales; Pseudomonadaceae; Pseudomonas aeruginosa; Micrococcaceae; Chemical synthesis; Enterobacteriaceae; Enterococcus; 1H-Pyrazol-5-amines; In vitro; Biological activity; Streptococcaceae; Streptococcus; Pyrimidine derivatives; Micrococcus; Antibacterial agent
• ISSN: 0960-894X; 0968-0896; 1464-3405; 1464-3391
• DOI: 10.1016/j.bmcl.2008.09.057

A one-pot and efficient method for the synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3- d]pyrimidine-dione derivatives by condensation reaction of barbituric acids, 1 H-pyrazol-5-amines and aldehydes under solvent-free conditions is reported. These products were evaluated in vitro for their antibacterial activities.