Insidious communication amongst cancer cells

The tumor microenvironment is home to various types of cognate and non-cognate cell interactions. Here we comment on a newly discovered form of intercellular communication, which is based on endoplasmic reticulum stress signaling. Through this mechanism transmitter cancer cells impart receiver cance...

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Bibliographic Details
Published inMolecular & cellular oncology Vol. 5; no. 3; p. e1356898
Main Authors Rodvold, Jeffrey J., Zanetti, Maurizio
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 04.05.2018
Taylor & Francis Group
Subjects
Chemoresistance
Er stress
Tumor heterogeneity
Tumor microenvironment
Tumor heterogeneity
Er stress
Tumor microenvironment
Chemoresistance
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Summary:The tumor microenvironment is home to various types of cognate and non-cognate cell interactions. Here we comment on a newly discovered form of intercellular communication, which is based on endoplasmic reticulum stress signaling. Through this mechanism transmitter cancer cells impart receiver cancer cells with resistance to secondary metabolic, pharmacologic and genotoxic stress, providing survival advantage. The implications of this finding are briefly discussed.
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ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2017.1356898