Evolution of bacterial meningitis diagnosis in São Paulo State-Brazil and future challenges

Bacterial meningitis (BM) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality. The most common cases of BM around the world, mainly in Brazil, have been caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influen...

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Published inArquivos de neuro-psiquiatria Vol. 71; no. 9B; pp. 672 - 676
Main Authors Salgado, Maristela Marques, Gonçalves, Maria Gisele, Fukasawa, Lucila Okuyama, Higa, Fábio Takenori, Paulino, Juliana Thalita, Sacchi, Cláudio Tavares
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Academia Brasileira de Neurologia - ABNEURO 01.09.2013
Academia Brasileira de Neurologia (ABNEURO)
Subjects
Bacteria
Bacterial meningitis
Brazil
Counterimmunoelectrophoresis
diagnostico molecular
Forecasting
Haemophilus influenzae
Humans
Meningite bacteriana
Meningitis, Bacterial - diagnosis
molecular diagnosis
Neisseria meningitidis
NEUROSCIENCES
PCR em tempo real
PSYCHIATRY
real time PCR
Real-Time Polymerase Chain Reaction
Streptococcus pneumoniae
Time Factors
Brazil
real time PCR
diagnostico molecular
PCR em tempo real
Bacterial meningitis
Meningite bacteriana
molecular diagnosis
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Summary:Bacterial meningitis (BM) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality. The most common cases of BM around the world, mainly in Brazil, have been caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b. Bacterial culture is the gold-standard technique for BM confirmation, but approximately 50% of suspected cases are not culture-confirmed, due to problems related to improper transportation and seeding or previous antibiotic treatment. Immunological methods present low sensitivity and have possibility of cross-reactions. Real time PCR (qPCR) is a molecular technique and has been successful used for BM diagnosis at Instituto Adolfo Lutz in São Paulo State, Brazil, since 2007. The incorporation of qPCR in the Public Health surveillance routine in our state resulted in diminishing 50% of undetermined BM cases. Our efforts are focused on qPCR implementation in the BM diagnostic routine throughout Brazil.
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ISSN:0004-282X
1678-4227
1678-4227
0004-282X
DOI:10.1590/0004-282X20130148