Effect of quinapril on intimal hyperplasia after coronary stenting as assessed by intravascular ultrasound

• Published in: The American journal of cardiology Vol. 87; no. 4; pp. 443 - 445
• Main Authors: Kondo, Junichiro, Sone, Takahito, Tsuboi, Hideyuki, Mukawa, Hiroaki, Kosokabe, Tai, Tsuzuki, Michitaka, Tomida, Takahito, Suzuki, Tomomichi, Kamiya, Hiroki, Hayashi, Kazunori, Matsui, Hideo, Okumura, Kenji
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.02.2001; Elsevier; Elsevier Limited
• Subjects: Aged; Angioplasty, Balloon; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Biological and medical sciences; Chi-Square Distribution; Coronary Angiography; Coronary Disease - diagnostic imaging; Coronary Disease - prevention & control; Coronary Disease - therapy; Coronary vessels; Diseases of the cardiovascular system; Female; Humans; Hyperplasia - prevention & control; Isoquinolines - therapeutic use; Male; Medical sciences; Middle Aged; Prospective Studies; Quinapril; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Recurrence; Stents; Studies; Tetrahydroisoquinolines; Treatment Outcome; Tunica Intima - pathology; Ultrasonic imaging; Ultrasonography, Interventional; Videotape Recording; Sonography; Human; Endoprosthesis; Quinapril; Radiodiagnosis; Treatment efficiency; Hyperplasia; Coronary artery; Instrumentation therapy; Exploration; Endovascular route; Coronary arteriography; Stent; Prevention; Chemotherapy; Treatment; Intima; Complication; ACE inhibitor; Quantitative analysis
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(00)01399-0

We studied whether angiotensin-converting enzyme inhibition with quinapril treatment can prevent in-stent restenosis after successful implantation of Palmaz-Schatz stents. Intravascular ultrasound study, but not quantitative coronary angiography analysis, revealed that quinapril treatment significantly prevented the loss of both minimal lumen cross-sectional area and lumen volume in stents, in addition to reducing the increase in intimal hyperplasia volume.