Mitochondrial Control in Inflammatory Gastrointestinal Diseases

• Published in: International journal of molecular sciences Vol. 23; no. 23; p. 14890
• Main Authors: Sui, Guo-Yan, Wang, Feng, Lee, Jin, Roh, Yoon Seok
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2022; MDPI
• Subjects: Apoptosis; Autophagy; Colorectal cancer; Colorectal Neoplasms - metabolism; Development and progression; Endoplasmic reticulum; Gastrointestinal system; Genomes; Homeostasis; Humans; Inflammation; Inflammatory Bowel Diseases - metabolism; Inflammatory diseases; Kinases; Lee, Y.S; Metabolism; Metabolites; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Mutation; Phosphorylation; Physiology; Proteins; Quality control; Review; Signal Transduction; Tumor necrosis factor-TNF; mitophagy; biogenesis; colorectal cancer; mitochondria; inflammatory bowel disease

Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of mu...