Mitochondrial Control in Inflammatory Gastrointestinal Diseases

Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of mu...

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Published inInternational journal of molecular sciences Vol. 23; no. 23; p. 14890
Main Authors Sui, Guo-Yan, Wang, Feng, Lee, Jin, Roh, Yoon Seok
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.12.2022
MDPI
Subjects
Apoptosis
Autophagy
Colorectal cancer
Colorectal Neoplasms - metabolism
Development and progression
Endoplasmic reticulum
Gastrointestinal system
Genomes
Homeostasis
Humans
Inflammation
Inflammatory Bowel Diseases - metabolism
Inflammatory diseases
Kinases
Lee, Y.S
Metabolism
Metabolites
Mitochondria
Mitochondria - metabolism
Mitochondrial DNA
Mutation
Phosphorylation
Physiology
Proteins
Quality control
Review
Signal Transduction
Tumor necrosis factor-TNF
mitophagy
biogenesis
colorectal cancer
mitochondria
inflammatory bowel disease
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Summary:Mitochondria play a central role in the pathophysiology of inflammatory bowel disease (IBD) and colorectal cancer (CRC). The maintenance of mitochondrial function is necessary for a stable immune system. Mitochondrial dysfunction in the gastrointestinal system leads to the excessive activation of multiple inflammatory signaling pathways, leading to IBD and increased severity of CRC. In this review, we focus on the mitochondria and inflammatory signaling pathways and its related gastrointestinal diseases.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232314890