Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution

• Published in: Journal of Virology Vol. 79; no. 21; pp. 13239 - 13249
• Main Authors: Allen, Todd M., Altfeld, Marcus, Geer, Shaun C., Kalife, Elizabeth T., Moore, Corey, O'Sullivan, Kristin M., DeSouza, Ivna, Feeney, Margaret E., Eldridge, Robert L., Maier, Erica L., Kaufmann, Daniel E., Lahaie, Matthew P., Reyor, Laura, Tanzi, Giancarlo, Johnston, Mary N., Brander, Christian, Draenert, Rika, Rockstroh, Jurgen K., Jessen, Heiko, Rosenberg, Eric S., Mallal, Simon A., Walker, Bruce D.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.11.2005
• Subjects: Acute Disease; Alleles; Amino Acid Sequence; Amino Acid Substitution; Biological and medical sciences; CD8-Positive T-Lymphocytes - immunology; Chronic Disease; Cohort Studies; Epitopes, T-Lymphocyte - genetics; Evolution, Molecular; Fundamental and applied biological sciences. Psychology; Genes, MHC Class I - genetics; Germany; HIV Infections - immunology; HIV Infections - virology; HIV-1 - genetics; HIV-1 - immunology; Human viral diseases; Humans; Infectious diseases; Lymphocyte Count; Medical sciences; Microbiology; Miscellaneous; Molecular Sequence Data; Mutation - immunology; Pathogenesis and Immunity; Polymorphism, Genetic; Selection, Genetic; Sequence Alignment; United States; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virology; United States; Germany; Immunopathology; Microbiology; HIV-1 virus; Retroviridae; AIDS; Cellular immunity; Immune deficiency; Lentivirus; Virology; Infection; Virus; Viral disease; Human immunodeficiency virus
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.79.21.13239-13249.2005

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