Idiopathic pulmonary fibrosis: Now less idiopathic?

Idiopathic pulmonary fibrosis (IPF) is a progressive diffuse fibrosing lung disease that kills increasing numbers of individuals each year with levels of mortality that exceed those of many cancers.1 It is an important lung problem for many reasons including being the most common of the diffuse fibr...

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Bibliographic Details
Published inRespiratory medicine Vol. 103; no. 6; pp. 791 - 792
Main Author du Bois, R.M
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2009
Elsevier Limited
Subjects
Diabetes
Diabetes Complications - complications
Disease
Gastroesophageal Reflux - complications
Humans
Idiopathic Pulmonary Fibrosis - etiology
Lung diseases
Lungs
Mortality
Pulmonary/Respiratory
Risk Factors
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Summary:Idiopathic pulmonary fibrosis (IPF) is a progressive diffuse fibrosing lung disease that kills increasing numbers of individuals each year with levels of mortality that exceed those of many cancers.1 It is an important lung problem for many reasons including being the most common of the diffuse fibrosing lung diseases and its awful prognosis. In two of these a higher incidence of gastro-oesophageal reflux was found in patients with IPF compared with normal individuals.7-9 In a third study, gastro-oesophageal reflux-induced oesophagitis was linked with pulmonary fibrosis.9 In a study of patients with end-stage IPF on a lung transplant waiting list, two thirds of were found to have gastro-oesophageal reflux.10 Interestingly, the typical symptoms (heartburn and regurgitation) could not distinguish between those with and without gastro-oesophageal reflux.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2009.03.014