Primary malignant melanoma of the vagina: A clinicopathological analysis of 10 cases

We retrospectively analyzed clinicopathological findings in 10 cases of primary malignant melanoma of the vagina. The main presenting symptoms were vaginal bleeding, vaginal discharge, and feeling of a mass. The tumors were predominantly located in the lowest one-third and in the anterolateral aspec...

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Published inGynecologic oncology Vol. 37; no. 2; pp. 264 - 267
Main Authors Borazjani, Gholamreza, Prem, Konald A., Okagaki, Takashi, Twiggs, Leo B., Adcock, Leon L.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.05.1990
Elsevier
Subjects
Biological and medical sciences
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Melanoma - mortality
Melanoma - pathology
Melanoma - surgery
Mitotic Index
Neoplasm Recurrence, Local
Survival
Time Factors
Tumors
Vagina - pathology
Vaginal Neoplasms - mortality
Vaginal Neoplasms - pathology
Vaginal Neoplasms - surgery
Human
Skin disease
Vagina
Malignant tumor
Female genital diseases
Case study
Pathology
Symptomatology
Treatment
Female genital system
Malignant melanoma
Evolution
Female
Tumor
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Summary:We retrospectively analyzed clinicopathological findings in 10 cases of primary malignant melanoma of the vagina. The main presenting symptoms were vaginal bleeding, vaginal discharge, and feeling of a mass. The tumors were predominantly located in the lowest one-third and in the anterolateral aspect of the vagina. Patients underwent various surgical procedures, radiation therapy, and chemotherapeutic modalities. The mean survival time and the recurrence time from the time of diagnosis were 15 and 8 months, respectively. The tumors were examined for histological characteristics of cell type, presence of melanin pigment, depth of invasion, vascular invasion, intraepithelial spread, junctional activity, and mitotic count. Of all these histological variables, the mean survival time had a significant correlation to mitotic count ( P < 0.04). We concluded that patients with lower mitotic counts (less than 6 per 10 HPF) had better survival (21 months) compared to patients with mitotic counts greater than 6 per 10 HPF who had a mean survival of only 7 months.
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ISSN:0090-8258
1095-6859
DOI:10.1016/0090-8258(90)90345-L