Basement membrane-related lncRNA signature for the prognosis of hepatocellular carcinoma

• Published in: Heliyon Vol. 10; no. 10; p. e30439
• Main Authors: Xun, Shenmei, Li, Xiaocui, Zhuang, Qingyuan, Zhu, Yefei, Qu, Lili
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30.05.2024; Elsevier
• Subjects: Basement membrane; Biomarkers; Hepatocellular carcinoma; lncRNAs; Prediction model; lncRNAs; Biomarkers; Hepatocellular carcinoma; Prediction model; Basement membrane
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e30439

Hepatocellular carcinoma (HCC) is the main type of primary liver cancer. This study aimed to develop a basement membrane (BM) related lncRNAs risk signature to evaluate the prognosis of HCC patients. We screened differentially expressed BM-related lncRNAs (DE-BMRlncRNAs) for risk evaluation, and identified six DE-BMRlncRNAs (AC072054.1, NUP50-DT, AC026412.3, AC109322.2, POLH-AS1 and LINC00595) for prognostic risk signature. HCC patients were divided to high or low risk according to median risk score. Our prognostic model predicted that patients with higher risk score had worse prognosis. We also created a nomogram to assist clinical decision-making according to risk score and clinicopathological features. Meanwhile, we confirmed the expression of six lncRNAs in HCC tissue and cells. POLH-AS1 knockdown inhibited the migration and invasion of HCC cells. In conclusion, we established a predictive model based on BMRlncRNAs to predict the prognosis of HCC. Our findings offer a rationale to further explore BM-related biomarkers for HCC.