Systolic versus diastolic heart failure in community practice: clinical features, outcomes, and the use of angiotensin-converting enzyme inhibitors

• Published in: The American journal of medicine Vol. 109; no. 8; pp. 605 - 613
• Main Authors: Philbin, Edward F, Rocco, Thomas A, Lindenmuth, Norman W, Ulrich, Kathleen, Jenkins, Paul L
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2000; Elsevier; Elsevier Sequoia S.A
• Subjects: Aged; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Biological and medical sciences; Cardiotonic agents; Cardiovascular system; Clinical trials; Diastole - drug effects; Drug Prescriptions - statistics & numerical data; Enzymes; Female; Heart failure; Heart Failure - drug therapy; Heart Failure - mortality; Heart Failure - physiopathology; Hospital Mortality; Hospitals, Community; Humans; Male; Medical sciences; Middle Aged; Patient Readmission; Pharmacology. Drug treatments; Quality of Life; Registries; Stroke Volume - drug effects; Survival Analysis; Systole - drug effects; Time Factors; Treatment Outcome; United States; Ventricular Function, Left - drug effects; United States; Human; Heart failure; Treatment efficiency; Clinical form; Cardiovascular disease; Survival; Quality of life; Chemotherapy; Heart disease; Diagnosis; Comparative study; ACE inhibitor; Ejection fraction
• ISSN: 0002-9343; 1555-7162
• DOI: 10.1016/S0002-9343(00)00601-X

BACKGROUND: Among patients with heart failure, there is controversy about whether there are clinical features and laboratory tests that can differentiate patients who have low ejection fractions from those with normal ejection fractions. The usefulness of angiotensin-converting enzyme (ACE) inhibitors among heart failure patients who have normal left ventricular ejection fractions is also not known. METHODS: From a registry of 2,906 unselected consecutive patients with heart failure who were admitted to 10 acute-care community hospitals during 1995 and 1997, we identified 1291 who had a quantitative measurement of their left ventricular ejection fraction. Patients were separated into three groups based on ejection fraction: ≤0.39 (n = 741, 57%), 0.40 to 0.49 (n = 238, 18%), and ≥0.50 (n = 312, 24%). In-hospital mortality, prescription of ACE inhibitors at discharge, subsequent rehospitalization, quality of life, and survival were measured; survivors were observed for at least 6 months after hospitalization. RESULTS: The mean (± SD) age of the sample was 75 ± 11 years; the majority (55%) of patients were women. In multivariate models, age >75 years, female sex, weight >72.7 kg, and a valvular etiology for heart failure were associated with an increased probability of having an ejection fraction ≥0.50; a prior history of heart failure, an ischemic or idiopathic cause of heart failure, and radiographic cardiomegaly were associated with a lower probability of having an ejection fraction ≥0.50. Total mortality was lower in patients with an ejection fraction ≥0.50 than in those with an ejection fraction ≤0.39 (odds ratio [OR] = 0.69, 95% confidence interval [CI]: 0.49 to 0.98, P = 0.04). Among hospital survivors with an ejection fraction of 0.40 to 0.49, the 65% who were prescribed ACE inhibitors at discharge had better mean adjusted quality-of-life scores (7.0 versus 6.2, P = 0.02), and lower adjusted mortality (OR = 0.34, 95% CI: 0.17 to 0.70, P = 0.01) during follow-up than those who were not prescribed ACE inhibitors. Among hospital survivors with an ejection fraction ≥0.50, the 45% who were prescribed ACE inhibitors at discharge had better (lower) adjusted New York Heart Association (NYHA) functional class (2.1 versus 2.4, P = 0.04) although there was no significant improvement in survival. CONCLUSIONS: Among patients treated for heart failure in community hospitals, 42% of those whose ejection fraction was measured had a relatively normal systolic function (ejection fraction ≥0.40). The clinical characteristics and mortality of these patients differed from those in patients with low ejection fractions. Among the patients with ejection fractions ≥0.40, the prescription of ACE inhibitors at discharge was associated favorable effects.