A systematic review: Sinomenine

Sinomenine (SIN), an alkaloid derived from the traditional Chinese medicine, Caulis Sinomenii, has been used as an anti-inflammatory drug in China for over 30 years. With the continuous increase in research on the pharmacological mechanism of SIN, it has been found that, in addition to the typical r...

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Published inHeliyon Vol. 10; no. 9; p. e29976
Main Authors Jiang, Shan, Li, Shuang, Pang, Siyuan, Liu, Mei, Sun, Huifeng, Zhang, Ning, Liu, Jianxin
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.05.2024
Elsevier
Subjects
Chronic inflammatory diseases
Natural compound
Pharmacological mechanism
Review
Rheumatoid arthritis
Sinomenine
Therapeutic drugs
Sinomenine
Natural compound
Therapeutic drugs
Pharmacological mechanism
Chronic inflammatory diseases
Rheumatoid arthritis
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Summary:Sinomenine (SIN), an alkaloid derived from the traditional Chinese medicine, Caulis Sinomenii, has been used as an anti-inflammatory drug in China for over 30 years. With the continuous increase in research on the pharmacological mechanism of SIN, it has been found that, in addition to the typical rheumatoid arthritis (RA) treatment, SIN can be used as a potentially effective therapeutic drug for anti-tumour, anti-renal, and anti-nervous system diseases. By reviewing a large amount of literature and conducting a summary analysis of the literature pertaining to the pharmacological mechanism of SIN, we completed a review that focused on SIN, found that the current research is insufficient, and offered an outlook for future SIN development. We hope that this review will increase the public understanding of the pharmacological mechanisms of SIN, discover SIN research trial shortcomings, and promote the effective treatment of immune diseases, inflammation, and other related diseases. [Display omitted]
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These authors contributed equally to this work and should be considered co-first authors.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e29976