Inflammation, a Key Event in Cancer Development
Several recent studies have identified nuclear factor-κB as a key modulator in driving inflammation to cancers. Besides this transcription factor, essential in regulating inflammation and cancer development, an inflammatory microenvironment inhabiting various inflammatory cells and a network of sign...
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Published in | Molecular cancer research Vol. 4; no. 4; pp. 221 - 233 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for Cancer Research
01.04.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Several recent studies have identified nuclear factor-κB as a key modulator in driving inflammation to cancers. Besides this
transcription factor, essential in regulating inflammation and cancer development, an inflammatory microenvironment inhabiting
various inflammatory cells and a network of signaling molecules are also indispensable for the malignant progression of transformed
cells, which is attributed to the mutagenic predisposition of persistent infection-fighting agents at sites of chronic inflammation.
As a subverted host response to inflammation-induced tumors, the inflammatory cells and regulators may facilitate angiogenesis
and promote the growth, invasion, and metastasis of tumor cells. Thus far, research regarding inflammation-associated cancer
development has focused on cytokines and chemokines as well as their downstream targets in linking inflammation and cancer.
Moreover, other proteins with extensive roles in inflammation and cancer, such as signal transducers and activators of transcription,
Nrf2, and nuclear factor of activated T cells, are also proposed to be promising targets for future studies. The elucidation
of their specific effects and interactions will accelerate the development of novel therapeutic interventions against cancer
development triggered by inflammation. (Mol Cancer Res 2006;4(4):221–33) |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1541-7786 1557-3125 |
DOI: | 10.1158/1541-7786.MCR-05-0261 |