Shared Mechanisms between Cardiovascular Disease and NAFLD

The burden of nonalcoholic fatty liver disease (NAFLD) is rising globally. Cardiovascular disease is the leading cause of death in patients with NAFLD. Nearly half of individuals with NAFLD have coronary heart disease, and more than a third have carotid artery atherosclerosis. Individuals with NAFLD...

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Bibliographic Details
Published inSeminars in liver disease Vol. 42; no. 4; p. 455
Main Authors Huang, Daniel Q, Downes, Michael, Evans, Ronald M, Witztum, Joseph L, Glass, Christopher K, Loomba, Rohit
Format Journal Article
LanguageEnglish
Published United States 01.11.2022
Subjects
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Humans
Inflammation - complications
Insulin Resistance
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - epidemiology
Risk Factors
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Summary:The burden of nonalcoholic fatty liver disease (NAFLD) is rising globally. Cardiovascular disease is the leading cause of death in patients with NAFLD. Nearly half of individuals with NAFLD have coronary heart disease, and more than a third have carotid artery atherosclerosis. Individuals with NAFLD are at a substantially higher risk of fatal and nonfatal cardiovascular events. NAFLD and cardiovascular disease share multiple common disease mechanisms, such as systemic inflammation, insulin resistance, genetic risk variants, and gut microbial dysbiosis. In this review, we discuss the epidemiology of cardiovascular disease in NAFLD, and highlight common risk factors. In addition, we examine recent advances evaluating the shared disease mechanisms between NAFLD and cardiovascular disease. In conclusion, multidisciplinary collaborations are required to further our understanding of the complex relationship between NAFLD and cardiovascular disease and potentially identify therapeutic targets.
ISSN:1098-8971
DOI:10.1055/a-1930-6658