Glioblastoma Multiforme—A Look at the Past and a Glance at the Future

Gliomas are the most common type of brain tumor that occur in adults and children. Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in adults and is universally fatal. The current standard-of-care options for GBM include surgical resection, radiotherapy, and concomit...

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Bibliographic Details
Published inPharmaceutics Vol. 13; no. 7; p. 1053
Main Authors King, Jasmine L., Benhabbour, Soumya Rahima
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 09.07.2021
MDPI
Subjects
blood–brain barrier (BBB)
blood–brain tumor barrier (BBTB)
Brain cancer
chemotherapy
glioblastoma
Kinases
Mutation
radiation
Radiation therapy
Review
surgery
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Summary:Gliomas are the most common type of brain tumor that occur in adults and children. Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in adults and is universally fatal. The current standard-of-care options for GBM include surgical resection, radiotherapy, and concomitant and/or adjuvant chemotherapy. One of the major challenges that impedes success of chemotherapy is the presence of the blood–brain barrier (BBB). Because of the tightly regulated BBB, immune surveillance in the central nervous system (CNS) is poor, contributing to unregulated glioma cell growth. This review gives a comprehensive overview of the latest advances in treatment of GBM with emphasis on the significant advances in immunotherapy and novel therapeutic delivery strategies to enhance treatment for GBM.
Bibliography:ObjectType-Article-2
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13071053