Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives

Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the de...

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Published inPharmaceutics Vol. 13; no. 10; p. 1657
Main Authors Cecen, Berivan, Karavasili, Christina, Nazir, Mubashir, Bhusal, Anant, Dogan, Elvan, Shahriyari, Fatemeh, Tamburaci, Sedef, Buyukoz, Melda, Kozaci, Leyla Didem, Miri, Amir K.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 11.10.2021
MDPI
Subjects
Automation
Biomedical materials
Cancer
Clinical trials
Design
Drugs
Endothelium
high-throughput screening
Liver
Metabolism
microfluidics
multi-organ-on-a-chip
Review
Skin
small drugs
Toxicity
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Summary:Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms.
Bibliography:These authors contributed equally to this work.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13101657