Compound C inhibits the replication of feline coronavirus

• Published in: Heliyon Vol. 10; no. 6; p. e27641
• Main Authors: Park, Yeonjeong, Kim, Chansoo, Park, Yea-In, Lee, Siyun, So, Jaeyeon, Park, Rackhyun, Park, Junsoo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30.03.2024; Elsevier
• Subjects: AMPK; Compound C; Feline coronavirus; Feline enteric coronavirus; Feline infectious peritonitis; Feline coronavirus; AMPK; Compound C; Feline infectious peritonitis; Feline enteric coronavirus
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e27641

Feline Coronavirus (FCoV) is a viral pathogen of cats and a highly contagious virus. Cats in a cattery can be infected by up to 100%, and even household cats are infected by 20–60%. Some strains of FCoV are known to induce a fatal disease in cats named Feline Infectious Peritonitis (FIP). However, no effective treatments are available. We demonstrated that compound C (dorsomorphin) can potentially inhibit feline coronavirus replication. Compound C treatment decreased the FCoV-induced plaque formation and cytopathic effect in FCoV-infected cells. Compound C treatment also significantly reduced the amount of viral RNA and viral protein in the cells in a dose-dependent manner. Our findings suggest that compound C is potentially useful for feline coronavirus-related diseases. •Compound C, an AMPK inhibitor, inhibits feline coronavirus replication.•Compound C reduces the expression of feline coronavirus protein and RNA.•Compound C alleviates FECV-induced cytopathic effect.