Upgrading the Transdermal Biomedical Capabilities of Thyme Essential Oil Nanoemulsions Using Amphiphilic Oligochitosan Vehicles

(1) Background: Thymus vulgaris L. (thyme) essential oil (TEO) has gained much attention because of its long history of medicinal usage. However, the lack of precise chemical profiling of the TEO and methods to optimize the bioactivity and delivery of its constituents has hampered its research on qu...

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Published inPharmaceutics Vol. 14; no. 7; p. 1350
Main Authors Nasr, Ali M., Mortagi, Yasmin I., Elwahab, Nashwa H. Abd, Alfaifi, Mohammad Y., Shati, Ali A., Elbehairi, Serag Eldin I., Elshaarawy, Reda F. M., Kamal, Islam
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 25.06.2022
MDPI
Subjects
anti-inflammatory
anti-melanoma
Antimicrobial agents
Bioavailability
Biopolymers
Cancer
Library collections
Nanoemulsions
Oils & fats
release kinetics
Surfactants
thyme oil multilayer nanoemulsions
transdermal delivery
United States > US
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Summary:(1) Background: Thymus vulgaris L. (thyme) essential oil (TEO) has gained much attention because of its long history of medicinal usage. However, the lack of precise chemical profiling of the TEO and methods to optimize the bioactivity and delivery of its constituents has hampered its research on quality control and biological function; (2) Methods: The current study aimed to analyze the TEO’s chemical composition using the GC-MS method and identify its key components. Another objective of this work is to study the impact of the protective layer of amphiphilic oligochitosan (AOC) on the physicochemical stability and transdermal potentials of TEO multilayer nanoemulsions formulated by the incorporation of TEO, Tween80, lecithin (Lec), and AOC; (3) Results: The AOC protective layer significantly improved the stability of TEO-based NEs as revealed by the constancy of their physicochemical properties (particle size and zeta potential) during storage for a week. Excessive fine-tuning of thyme extract NEs and the AOC protective layer’s persistent positive charge have been contributed to the thyme extract’s improved anti-inflammatory, transdermal, and anti-melanoma potentials; (4) Conclusions: the AOC-coated NEs could offer novel multifunctional nanoplatforms for effective transdermal delivery of lipophilic bioactive materials.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14071350