Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction

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Published inJournal of Virology Vol. 81; no. 17; pp. 9249 - 9258
Main Authors GOLDEN-MASON, Lucy, PALMER, Brent, KLARQUIST, Jared, MENGSHOL, John A, CASTELBLANCO, Nicole, ROSEN, Hugo R
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.09.2007
Subjects
Adult
Antibodies, Monoclonal
Antigens, CD - biosynthesis
Antigens, CD - immunology
Apoptosis Regulatory Proteins - biosynthesis
B7-H1 Antigen
Biological and medical sciences
Blood - immunology
CD57 Antigens - analysis
CD8-Positive T-Lymphocytes - immunology
Cell Proliferation
Cytomegalovirus - immunology
Cytomegalovirus Infections - immunology
Female
Fundamental and applied biological sciences. Psychology
Hepacivirus - immunology
Hepatitis C, Chronic - immunology
Humans
Intercellular Signaling Peptides and Proteins - immunology
Interferon-gamma - biosynthesis
Interleukin-2 - biosynthesis
Liver - immunology
Male
Microbiology
Middle Aged
Miscellaneous
Pathogenesis and Immunity
Programmed Cell Death 1 Ligand 2 Protein
Programmed Cell Death 1 Receptor
T-Lymphocyte Subsets - immunology
Up-Regulation
Virology
Virus
Dysfunction
T-Lymphocyte
Flaviviridae
Hepatitis C virus
Hepacivirus
Virology
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content type line 23
Corresponding author. Mailing address: Division of Gastroenterology/Hepatology, UCHSC GI Division, 4200 East Ninth Ave., #B-158, Denver, CO 80262. Phone: (303) 315-2536. Fax: (303) 315-5711. E-mail: Hugo.Rosen@UCHSC.edu
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00409-07