Cognitive deficits and striato-frontal dopamine release in Parkinson's disease

• Published in: Brain (London, England : 1878) Vol. 131; no. 5; pp. 1294 - 1302
• Main Authors: Sawamoto, Nobukatsu, Piccini, Paola, Hotton, Gary, Pavese, Nicola, Thielemans, Kris, Brooks, David J.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2008; Oxford Publishing Limited (England)
• Subjects: 11C-raclopride positron emission tomography; Adult; anterior cingulate cortex; Biological and medical sciences; Cognition Disorders - diagnostic imaging; Cognition Disorders - etiology; Cognition Disorders - metabolism; Corpus Striatum - diagnostic imaging; Corpus Striatum - metabolism; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dopamine - metabolism; Dopamine Antagonists; dopamine D2-receptor; dorsal caudate; Female; Frontal Lobe - diagnostic imaging; Frontal Lobe - metabolism; Humans; Image Interpretation, Computer-Assisted - methods; Male; Medical sciences; Middle Aged; Neurology; Neuropsychological Tests; Parkinson Disease - diagnostic imaging; Parkinson Disease - metabolism; Parkinson Disease - psychology; Parkinson's disease; Positron-Emission Tomography - methods; Raclopride; Receptors, Dopamine D2 - metabolism; spatial working memory; dopamine D2-receptor; C-raclopride positron emission tomography; dorsal caudate; anterior cingulate cortex; spatial working memory; Nervous system diseases; Dopamine; Cognitive disorder; Central nervous system; Parkinson disease; Catecholamine; Encephalon; Cerebral disorder; D2 Dopamine receptor; Cingulate cortex; Central nervous system disease; Neurotransmitter; Frontal; Degenerative disease; Working memory; Release; Extrapyramidal syndrome; Spatial memory
• ISSN: 0006-8950; 1460-2156
• DOI: 10.1093/brain/awn054

Idiopathic Parkinson's disease (PD) is often accompanied by a pattern of executive deficits similar to those found in patients with frontal lobe lesions. We investigated whether such cognitive deficits are attributable to frontal lobe dysfunction as a direct consequence of impaired mesocortical dopaminergic transmission or an indirect consequence of impaired nigrostriatal dopaminergic function. For this purpose, changes in synaptic dopamine levels during task performance were monitored using a marker of dopamine D2-receptor availability 11C-raclopride (RAC) PET. During RAC PET, seven patients with early symptomatic PD and seven age-matched healthy controls performed two types of behavioural task, a spatial working memory task (SWT) and a visuomotor control task (VMT). The SWT involves an executive process which is known to be impaired by both frontal lobe lesions and PD while the VMT is a control test for the visuomotor component of the SWT. Parametric images of RAC binding potential during performance of each task were generated, and compared between the tasks using voxel-based statistical parametric mapping as well as region of interest analysis. In controls, RAC binding was reduced in the dorsal caudate during performance of the SWT compared with the VMT, compatible with increased levels of endogenous dopamine release due to the executive process. In PD patients, this RAC binding reduction was not observed. In contrast, RAC binding in the anterior cingulate cortex within the medial prefrontal cortex was reduced by a comparable level during the SWT both in controls and PD patients. Statistical comparisons between controls and PD patients confirmed significantly attenuated dopamine release in the dorsal caudate in PD, but preserved levels of medial prefrontal dopamine release. Our data suggest that executive deficits in early patients with PD are associated with impaired nigrostriatal dopaminergic function resulting in abnormal processing in the cortico-basal ganglia circuit. In contrast, mesocortical dopaminergic transmission appears well preserved in early PD patients.