A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease

• Published in: The New England journal of medicine Vol. 361; no. 26; pp. 2538 - 2547
• Main Authors: Omland, Torbjørn, de Lemos, James A, Sabatine, Marc S, Christophi, Costas A, Rice, Madeline Murguia, Jablonski, Kathleen A, Tjora, Solve, Domanski, Michael J, Gersh, Bernard J, Rouleau, Jean L, Pfeffer, Marc A, Braunwald, Eugene
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 24.12.2009
• Subjects: Angina pectoris; Biomarkers - blood; Cardiology; Cardiovascular disease; Cardiovascular Diseases - mortality; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Female; Follow-Up Studies; Heart attacks; Heart Failure - epidemiology; Heart Failure - mortality; Hospitalization - statistics & numerical data; Humans; Incidence; Male; Middle Aged; Myocardial Infarction - epidemiology; Myocardial Infarction - mortality; Prognosis; Randomized Controlled Trials as Topic; Sensitivity and Specificity; Troponin T - blood; Ventricular Function, Left
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa0805299

In a retrospective analysis from a randomized trial, stored serum samples from patients with stable coronary artery disease were analyzed with the use of a new, highly sensitive assay for cardiac troponin T. At levels well below the limit of detection of the conventional assay, troponin T concentrations correlated significantly with the subsequent risk of cardiovascular death and heart failure but not with the risk of myocardial infarction. This retrospective analysis used a new, highly sensitive assay for cardiac troponin T. At levels well below the limit of detection of the conventional assay, troponin T concentrations correlated significantly with the subsequent risk of cardiovascular death and heart failure but not with the risk of myocardial infarction. Cardiac troponins T and I are components of the contractile apparatus of cardiomyocytes and are the preferred biochemical markers of myocardial necrosis in patients with suspected acute coronary syndromes. 1 Among such patients, a strong association between elevated troponin levels and recurrent coronary ischemic events has been firmly established. 2 – 4 It has been shown that even very small elevations in troponins are associated with an increased risk of an adverse outcome in patients with acute coronary syndromes. 5 Moreover, among men clinically free of cardiovascular disease, as well as in patients with recent acute coronary syndromes, levels of cardiac troponin greater than . . .