Functional evaluation of mineral trioxide aggregate cement with choline dihydrogen phosphate

• Published in: Dental Materials Journal Vol. 42; no. 4; pp. 485 - 492
• Main Authors: TABIRA, Kazuhisa, KAJIMOTO, Noboru, MINAMISAWA, Hirogo, SATO, Taira, MARUTA, Michito, OKA, Kyoko, KATAOKA, Takuya, YOSHIOKA, Tomohiko, HAYAKAWA, Satoshi, TSURU, Kanji
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society for Dental Materials and Devices 25.07.2023; Japan Science and Technology Agency
• Subjects: Biocompatibility; Cell proliferation; Cell viability; Cement; Choline; Choline dihydrogen phosphate (CDHP); Cytocompatibility; Hydroxyapatite; Low crystalline hydroxyapatite; Mineral trioxide aggregate (MTA); Reparative dentin; Tensile strength; Reparative dentin; Cytocompatibility; Mineral trioxide aggregate (MTA); Choline dihydrogen phosphate (CDHP); Low crystalline hydroxyapatite
• ISSN: 0287-4547; 1881-1361
• DOI: 10.4012/dmj.2022-283

To improve the cytocompatibility of mineral trioxide aggregate (MTA) cement and its ability for reparative dentin formation, the effect of adding choline dihydrogen phosphate (CDHP), which is reported to be biocompatible, to MTA cement was investigated. The L929 cell proliferation showed that the addition of CDHP improved cell viability. The addition of CDHP shortened the setting time of MTA cement, with a significant decrease in consistency above 0.4 g/mL. Diametral tensile strength of the set cement was improved by the addition of 0.4 g/mL CDHP. Solubility was judged to be within the range of clinical application. The spontaneous precipitation of low crystalline hydroxyapatite was examined by immersing the set cement in phosphate buffer saline, and it was found that the ability of the cement with 0.4 g/mL of CDHP was significantly improved compared with that of the cement without CDHP.