IDH1 and IDH2: Not Your Typical Oncogenes

Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.

Saved in:
Bibliographic Details
Published inCancer cell Vol. 17; no. 3; pp. 215 - 216
Main Authors Reitman, Zachary J., Parsons, D. Williams, Yan, Hai
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.03.2010
Online AccessGet full text

Cover

More Information
Summary:Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2010.02.024