The causal effect of oxidative stress on the risk of glaucoma
Glaucoma is a complex multifactorial disease. Oxidative stress has been implicated in its pathogenesis. However, establishing a causal relationship between oxidative stress and glaucoma is challenging due to confounding and reverse causality. In this study, we performed bidirectional two-sample Mend...
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Published in | Heliyon Vol. 10; no. 3; p. e24852 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
15.02.2024
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Glaucoma is a complex multifactorial disease. Oxidative stress has been implicated in its pathogenesis. However, establishing a causal relationship between oxidative stress and glaucoma is challenging due to confounding and reverse causality. In this study, we performed bidirectional two-sample Mendelian randomization (MR) analyses based on genetic instrumental variables as proxies for 11 biomarkers of oxidative stress injury to investigate the causal relationship between oxidative stress and glaucoma. Eight significant associations were identified. Increased circulating levels of catalase (OR = 0.915, 95 % CI: 0.848–0.987, P = 0.022), retinol (OR = 0.481, 95 % CI: 0.248–0.932, P = 0.044) and superoxide dismutase (OR = 0.779, 95 % CI: 0. 616-0.986, P = 0.038) are associated with a decreased risk of glaucoma, whereas an increased myeloperoxidase level (OR = 2.145, 95 % CI: 1.119–4.111, P = 0.029) is associated with an increased risk of glaucoma. Glaucoma was causally associated with lower levels of total bilirubin (OR = 0.961, 95 % CI: 0.927–0.997, P = 0.039), glutathione peroxidase (OR = 0. 934, 95 % CI: 0.890–0.981, P = 0.006), paraoxonase (OR = 0.883, 95 % CI: 0.810–0.963, P = 0.005) and albumin (OR = 0.988, 95 % CI: 0.978–0.998, P = 0.014). The bidirectional MR analysis revealed a causal relationship between oxidative stress and glaucoma. These findings provide a greater understanding of the underlying mechanisms of glaucomatous neurodegeneration and imply a potential therapeutic approach for glaucoma through targeting oxidative stress pathways. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors wish it to be known that, in their opinion, the first three authors should be regarded as joint First Authors. |
ISSN: | 2405-8440 2405-8440 |
DOI: | 10.1016/j.heliyon.2024.e24852 |