Non-alcoholic fatty liver disease: Definition and subtypes

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide, with a global prevalence of approximately 30%. However, the prevalence of NAFLD has been variously reported depending on the comorbidities. The rising prevalence of obesity in both the adult and pediatric p...

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Published inClinical and molecular hepatology Vol. 29; no. Suppl; pp. S5 - S16
Main Authors Han, Seul Ki, Baik, Soon Koo, Kim, Moon Young
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Association for the Study of the Liver 01.02.2023
The Korean Association for the Study of the Liver
Subjects
Biopsy
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - etiology
Diabetes
Fatty liver
Fibrosis
Hepatitis
Humans
Hypertension
Inflammation
Insulin resistance
Liver cancer
Liver cirrhosis
Liver Cirrhosis - complications
Liver diseases
Liver Neoplasms - complications
Liver Neoplasms - diagnosis
Liver Neoplasms - epidemiology
Magnetic resonance imaging
Meta-analysis
Metabolism
non-alcoholic fatty liver disease
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - diagnosis
Non-alcoholic Fatty Liver Disease - epidemiology
Review
Risk factors
Spectrum analysis
steatohepatitis
United States > US
Non-alcoholic fatty liver disease
Steatohepatitis
Fibrosis
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Summary:Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide, with a global prevalence of approximately 30%. However, the prevalence of NAFLD has been variously reported depending on the comorbidities. The rising prevalence of obesity in both the adult and pediatric populations is projected to consequently continue increasing NAFLD prevalence. It is a major cause of chronic liver disease worldwide, including cirrhosis and hepatocellular carcinoma (HCC). NAFLD has a variety of clinical phenotypes and heterogeneity due to the complexity of pathogenesis and clinical conditions of its occurrence, resulting in various clinical prognoses. In this article, we briefly described the basic definition of NAFLD and classified the subtypes based on current knowledge in this field.
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Editor: Jung-Hwan Yu, Inha University Hospital, Korea
ISSN:2287-2728
2287-285X
2287-285X
DOI:10.3350/cmh.2022.0424