Clinical Utility of HIV Standard Genotyping among Antiretroviral-Naive Individuals with Unknown Duration of Infection

• Published in: Clinical infectious diseases Vol. 44; no. 3; pp. 456 - 458
• Main Authors: Smith, Davey, Moini, Niousha, Pesano, Rick, Cachay, Edward, Aiem, Heidi, Lie, Yolanda, Richman, Douglas, Little, Susan
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.02.2007; University of Chicago Press; Oxford University Press
• Subjects: AIDS; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretrovirals; Antiviral agents; Antivirals; Biological and medical sciences; California - epidemiology; Clinical outcomes; Disease transmission; Drug resistance; Drug Resistance, Multiple, Viral - drug effects; Drug Resistance, Multiple, Viral - genetics; Female; Genetic mutation; Genotype; Genotype & phenotype; HIV; HIV - drug effects; HIV - genetics; HIV 1; HIV infections; HIV Infections - drug therapy; HIV Infections - genetics; HIV/AIDS; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infections; Infectious diseases; Male; Medical sciences; Patient care; Patient Care Planning; Pharmacology. Drug treatments; Prevalence; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; California; Human; Immunopathology; Antiretroviral agent; Typing; Retroviridae; Genotype; AIDS; Duration; Immune deficiency; Lentivirus; Standards; Infection; Virus; Microbiological investigation; Viral disease; Antiviral; Human immunodeficiency virus
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/510748

In clinical settings, we have found a high rate of human immunodeficiency virus (HIV) drug resistance among antiretroviral-naive patients for whom the duration of infection was unknown. These high rates were most likely the result of both transmitted resistance and informal antiretroviral use, and they suggest that routine resistance testing among antiretroviral-naive patients would be a cost-effective clinical practice.