Dietary diphenyl diselenide reduces the STZ-induced toxicity

• Published in: Food and chemical toxicology Vol. 46; no. 1; pp. 186 - 194
• Main Authors: Barbosa, N.B.V., Rocha, J.B.T., Soares, J.C.M., Wondracek, D.C., Gonçalves, J.F., Schetinger, M.R.C., Nogueira, C.W.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 2008; New York, NY Elsevier Science
• Subjects: 5'-Nucleotidase - metabolism; Animals; Antioxidants - metabolism; Benzene Derivatives - pharmacology; Biological and medical sciences; Blood Glucose - metabolism; Body Weight - drug effects; Catalase - metabolism; Diabetes; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - prevention & control; Diabetes. Impaired glucose tolerance; Diet; Diphenyl diselenide; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Hyperglycemia; Male; Medical sciences; Organ Size - drug effects; Organoselenium Compounds - pharmacology; Oxidative stress; Porphobilinogen Synthase - metabolism; Rats; Rats, Wistar; Selenium - analysis; Sodium-Potassium-Exchanging ATPase - metabolism; Sulfhydryl Compounds - metabolism; Toxicology; δ-ALA-D; Oxidative stress; Hyperglycemia; CAT; ROS; STZ; Diphenyl diselenide; Diabetes; Endocrinopathy; Nutrition; Diet; Toxicity; Diabetes mellitus; Oral administration; Feeding
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2007.07.014

Oxidative stress is implicated in the pathogenesis of diabetes mellitus. Selenium supplementation has some benefits in experimental models of diabetes mellitus. This study evaluated whether dietary diphenyl diselenide, a simple synthetic organoselenium compound with antioxidant properties, reduces the streptozotocin (STZ)-induced toxicity. STZ-induced diabetic rats were fed with either standard and diphenyl diselenide (10 ppm) supplemented diets. In experimental trials, dietary diphenyl diselenide significantly decreased mortality rate ( p < 0.05) induced by STZ treatment. No correlation between this effect and glycemic levels were found. Diphenyl diselenide intake also promoted an increase in vitamin C, –SH levels (liver, kidney and blood) and in catalase (liver and kidney) activity, which were decreased in STZ-treated rats. In enzyme assays, diphenyl diselenide supplementation caused a significant improvement in platelets NTPDase and 5′-nucleotidase activities in STZ-induced diabetic rats when compared to the control and diabetic groups ( p < 0.05). Nevertheless, this supplementation did not modify the inhibition induced by STZ in δ-ALA-D activity. Our findings suggest that diphenyl diselenide compound showed beneficial effects against the development of diabetes by exhibiting antioxidant properties.