In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites

• Published in: Advanced materials (Weinheim) Vol. 27; no. 40; pp. 6125 - 6130
• Main Authors: Zhang, Di, Qi, Guo-Bin, Zhao, Ying-Xi, Qiao, Sheng-Lin, Yang, Chao, Wang, Hao
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 28.10.2015
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Assembly; Biomedical materials; Cell Line, Tumor; chlorophyll; Circular Dichroism; Conjugates; Effectiveness; Etoposide; Gelatinases - chemistry; Imaging; Mice; Microscopy, Electron, Transmission; Nanofibers; Nanofibers - chemistry; nanomaterials; Neoplasm Transplantation; photoacoustic imaging; Photoacoustic Techniques - methods; Porphyrins - chemical synthesis; Porphyrins - chemistry; Porphyrins - pharmacology; Precursors; supramolecular structures; Temperature; Time Factors; Tomography, Optical; tumor therapies; Tumors; chlorophyll; nanomaterials; tumor therapies; photoacoustic imaging; supramolecular structures

An assembly‐induced retention effect for enhanced tumor photoacoustic (PA) imaging and therapeutics is described. A responsive small‐molecule precursor is prepared that simultaneously self‐assembles into nanofibers in tumor sites that exhibit an assembly‐induced retention effect, which results in an...