In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites

• Published in: Advanced materials (Weinheim) Vol. 27; no. 40; pp. 6125 - 6130
• Main Authors: Zhang, Di, Qi, Guo-Bin, Zhao, Ying-Xi, Qiao, Sheng-Lin, Yang, Chao, Wang, Hao
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 28.10.2015
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Assembly; Biomedical materials; Cell Line, Tumor; chlorophyll; Circular Dichroism; Conjugates; Effectiveness; Etoposide; Gelatinases - chemistry; Imaging; Mice; Microscopy, Electron, Transmission; Nanofibers; Nanofibers - chemistry; nanomaterials; Neoplasm Transplantation; photoacoustic imaging; Photoacoustic Techniques - methods; Porphyrins - chemical synthesis; Porphyrins - chemistry; Porphyrins - pharmacology; Precursors; supramolecular structures; Temperature; Time Factors; Tomography, Optical; tumor therapies; Tumors; chlorophyll; nanomaterials; tumor therapies; photoacoustic imaging; supramolecular structures
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.201502598

An assembly‐induced retention effect for enhanced tumor photoacoustic (PA) imaging and therapeutics is described. A responsive small‐molecule precursor is prepared that simultaneously self‐assembles into nanofibers in tumor sites that exhibit an assembly‐induced retention effect, which results in an improved PA imaging signal and enhanced therapeutic efficacy. This successful proof‐of‐concept study paves the way to develop novel supramolecular biomaterials for cancer diagnostics and therapeutics.