Current prescription pattern of maintenance treatments for bipolar patients in Korea: A focus on the transition from acute treatments

• Published in: Psychiatry and clinical neurosciences Vol. 70; no. 1; pp. 42 - 50
• Main Authors: Song, Hoo Rim, Kwon, Young‐Joon, Bahk, Won‐Myong, Woo, Young Sup, Lee, Hwang‐Bin, Lee, Jonghun, Lee, Dae‐Bo, Lee, Sang‐Yeol, Kim, Moon‐Doo, Won, Seunghee, Lee, Kwanghun, Sohn, Inki, Lee, Jung Goo, Shin, Young‐Chul, Chung, Sangkeun, Jang, Saeheon, Jae, Young Myo, Yoon, Bo‐Hyun
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.01.2016
• Subjects: Adult; Bipolar disorder; Bipolar Disorder - drug therapy; Drug Therapy, Combination - statistics & numerical data; Female; Humans; Maintenance Chemotherapy; maintenance treatment; Male; Middle Aged; Practice Patterns, Physicians' - statistics & numerical data; Psychiatry; Psychotropic Drugs - therapeutic use; recovery; Remission Induction; Republic of Korea; Retrospective Studies; Time Factors; bipolar disorder; maintenance treatment; recovery
• ISSN: 1323-1316; 1440-1819
• DOI: 10.1111/pcn.12337

Aims We examined prescription patterns in maintenance treatment for recovered bipolar patients and compared these with acute treatments. Methods Using retrospective methods, the bipolar patients in clinical recovery (Clinical Global Impression Bipolar Version score ≤ 2 for 6 months) after acute episode were selected. We reviewed differences between prescription patterns at remission and after a maintenance period of at least 6 months. Results A total of 340 bipolar disorder patients were selected. During the maintenance period, more than half of the patients (192, 56.5%) took a mood stabilizer (MS) + antipsychotic (AP) combination. Among the MS, valproate (149, 43.8%) was most prescribed, and lithium (98, 28.8%) was second, but as patients moved into maintenance treatment, lithium use decreased, and the use of lamotrigine (86, 25.3%) increased. Preferred AP were quetiapine (125, 36.8%), aripiprazole (67, 19.7%), risperidone (48, 14.1%), and olanzapine (39, 11.5%). The use of olanzapine in maintenance was greatly decreased compared with that during acute treatment (67, 19.7%). Most patients did not take an antidepressant (AD), but the proportion using one or more AD was increased during maintenance (17.9% to 30.3%), and bupropion (28, 8.2%) was the preferred AD. Doses were decreased in all drugs, but lamotrigine was maintained at a dose of 133.2 ± 68.5 mg/day. Conclusions The most common prescription combination for bipolar maintenance treatment was MS + AP. The use of AP was decreased, whereas the use of AD in combination with MS and/or AP was increased. The doses of MS and AP were generally decreased during the maintenance periods, with the exception of lamotrigine.