3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co‐printing multiple materials, known as bioinks, in three dimensions. These 3D mi...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 26; no. 19; pp. 3124 - 3130
Main Authors Kolesky, David B., Truby, Ryan L., Gladman, A. Sydney, Busbee, Travis A., Homan, Kimberly A., Lewis, Jennifer A.
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 21.05.2014
Subjects
3D printing
biomaterials
Bioprinting
Construction
Drugs
Extracellular Matrix - chemistry
Heterogeneous structure
Human Umbilical Vein Endothelial Cells
Humans
Poloxamer - chemistry
Polyethylene Glycols - chemistry
Propylene Glycols - chemistry
Screening
Three dimensional
Three dimensional printing
Tissue Engineering
vasculature
Wound healing
vasculature
tissue engineering
biomaterials
3D printing
bioprinting
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Summary:A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co‐printing multiple materials, known as bioinks, in three dimensions. These 3D micro‐engineered environments open new ­avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem‐cell niches.
Bibliography:istex:BE89EE44C2FC22EAC326E07365CBCA1DE8FB73DB
ark:/67375/WNG-BSX7J2XV-B
National Science Foundation Graduate Research Fellowship Program - No. DGE1144152
ArticleID:ADMA201305506
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201305506