Studies on Non-sesquiterpenoid Constituents of Gaillardia pulchella. II. Less Lipophilic Substances, Methyl Caffeate as an Antitumor Catecholic

• Published in: Chem. Pharm. Bull Vol. 32; no. 3; pp. 1135 - 1141
• Main Authors: HARIMAYA, KENZO, HIKICHI, MANABU, KAWAMATA, TAKESHI, HORI, HITOSHI, YOKOKURA, TERUO, OHKURA, TAMIKO, INAYAMA, SEIICHI
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1984; 公益社団法人日本薬学会; Maruzen; Japan Science and Technology Agency
• Subjects: Animals; antimicrobial activity; Antineoplastic Agents, Phytogenic - isolation & purification; antitumor activity; benzaldehyde; Biological and medical sciences; Caffeic Acids - isolation & purification; Caffeic Acids - pharmacology; catecholylpropionoid; Chemical Phenomena; Chemistry; Cinnamates - isolation & purification; Compositae; Gaillardia pulchella; General pharmacology; Male; Medical sciences; methanol extraction; methyl caffeate; Mice; Mice, Inbred ICR; non-sesquiterpenoid; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal - analysis; synthetic catecholic; Antineoplastic agent; Dicotyledones; Angiospermae; Isolation; Active ingredient; Spermatophyta; Compositae
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.32.1135

A less lipophilic non-sesquiterpenoid antitumor constituent, methyl caffeate, along with D-fructose, was isolated from the aqueous methanol extract of the dried whole plant of Gaillardia pulchella. Among forty-three synthetic catechol analogues related to methyl caffeate tested for antitumor activity against Sarcoma 180 in mice, acetates of methyl catecholylpropionoid type showed stronger activity than the corresponding catechuic acid and catechualdehyde derivatives as well as simple benzaldehyde (so-called vidrol). None of the catecholic and related compounds tested showed significant antimicrobial activity in vitro.