COVID‐19‐associated myocardial injury: A case report

Coronavirus disease 2019 (COVID‐19) is often accompanied by pneumonia and can be fatal. We report a case of COVID‐19‐associated myocardial injury mimicking fulminant myocarditis. Endomyocardial biopsy revealed numerous von Willebrand factor‐rich microthrombi with small myocardial necrotic areas, com...

Full description

Saved in:
Bibliographic Details
Published inESC Heart Failure Vol. 10; no. 2; pp. 1461 - 1466
Main Authors Tadokoro, Tomonori, Ohta‐Ogo, Keiko, Ikeda, Yoshihiko, Sugiyama, Masaya, Katano, Harutaka, Hatakeyama, Kinta, Matsumoto, Masanori, Tashiro, Hideki
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.04.2023
John Wiley and Sons Inc
Wiley
Subjects
Antibodies
Autopsies
Biopsy
Case Report
Case Reports
Cell growth
Chemokines
Complement
Coronaviruses
COVID-19
COVID-19 - complications
Cytokines
Ejection fraction
Electrocardiography
Endothelial injury
Extracorporeal membrane oxygenation
Growth factors
Heart
Hospitalization
Humans
Interferon
Ischemia
Ligands
Macrophage infiltration
Microthrombi
Myocardial Infarction
Myocardial injury
Myocarditis
Myocarditis - diagnosis
Myocarditis - etiology
Necrosis
Patients
Pneumonia
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Stem cells
Steroids
Tomography
COVID-19
Macrophage infiltration
Complement
Endothelial injury
Microthrombi
Myocardial injury
Online AccessGet full text

Cover

More Information
Summary:Coronavirus disease 2019 (COVID‐19) is often accompanied by pneumonia and can be fatal. We report a case of COVID‐19‐associated myocardial injury mimicking fulminant myocarditis. Endomyocardial biopsy revealed numerous von Willebrand factor‐rich microthrombi with small myocardial necrotic areas, complement deposits in small vessels/microthrombi, and macrophage‐predominant interstitial infiltration. These findings, distinct from those of typical lymphocytic myocarditis, show diffuse endothelial injury, complement activation, and activated macrophages as characteristic features of COVID‐19‐associated pathogenesis. Dysregulated serum cytokine profiles predicting severe/critical COVID‐19‐associated myocardial injury were also determined. This case emphasizes the occurrence of fatal cardiac manifestation with microthrombotic injury in the early stage of COVID‐19.
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.14295