Protective effects of melatonin against oxidative injury in rat testis induced by wireless (2.45 GHz) devices

• Published in: Andrologia Vol. 46; no. 1; pp. 65 - 72
• Main Authors: Oksay, T., Naziroğlu, M., Doğan, S., Güzel, A., Gümral, N., Koşar, P. A.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.02.2014
• Subjects: Animals; Antioxidants; Electromagnetic radiation; Glutathione - metabolism; Glutathione peroxidase; Lipid peroxidation; Lipids; Male; Malondialdehyde - metabolism; Melatonin; Melatonin - pharmacology; Organ Size - drug effects; Organ Size - radiation effects; Oxidative stress; Oxidative Stress - drug effects; Radio Waves; rat; Rats; Rats, Wistar; Reproductive organs; Supplements; testis; Testis - drug effects; Testis - metabolism; Testis - radiation effects; Vitamin A; Vitamin E; wireless devices; Melatonin; wireless devices; testis; rat; oxidative stress
• ISSN: 0303-4569; 1439-0272
• DOI: 10.1111/and.12044

Summary Wireless devices have become part of everyday life and mostly located near reproductive organs while they are in use. The present study was designed to determine the possible protective effects of melatonin on oxidative stress–dependent testis injury induced by 2.45‐GHz electromagnetic radiation (EMR). Thirty‐two rats were equally divided into four different groups, namely cage control (A1), sham control (A2), 2.45‐GHz EMR (B) and 2.45‐GHz EMR+melatonin (C). Group B and C were exposed to 2.45‐GHz EMR during 60 min day−1 for 30 days. Lipid peroxidation levels were higher in Group B than in Group A1 and A2. Melatonin treatment prevented the increase in the lipid peroxidation induced by EMR. Also reduced glutathione (GSH) and glutathione peroxidase (GSH‐Px) levels in Group D were higher than that of exposure group. Vitamin A and E concentrations decreased in exposure group, and melatonin prevented the decrease in vitamin E levels. In conclusion, wireless (2.45 GHz) EMR caused oxidative damage in testis by increasing the levels of lipid peroxidation and decreasing in vitamin A and E levels. Melatonin supplementation prevented oxidative damage induced by EMR and also supported the antioxidant redox system in the testis.