The Function of Fish Cytokines

What is known about the biological activity of fish cytokines is reviewed. Most of the functional studies performed to date have been in teleost fish, and have focused on the induced effects of cytokine recombinant proteins, or have used loss- and gain-of-function experiments in zebrafish. Such stud...

Full description

Saved in:
Bibliographic Details
Published inBiology (Basel, Switzerland) Vol. 5; no. 2; p. 23
Main Authors Zou, Jun, Secombes, Christopher J
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 24.05.2016
MDPI AG
Subjects
bioactivity
colony stimulating factors
cytokines
interferons
interleukins
loss- and gain-of-function
recombinant proteins
Review
transforming growth factor-β
tumour necrosis factors
colony stimulating factors
interferons
bioactivity
transforming growth factor-β
recombinant proteins
cytokines
tumour necrosis factors
loss- and gain-of-function
interleukins
Online AccessGet full text

Cover

More Information
Summary:What is known about the biological activity of fish cytokines is reviewed. Most of the functional studies performed to date have been in teleost fish, and have focused on the induced effects of cytokine recombinant proteins, or have used loss- and gain-of-function experiments in zebrafish. Such studies begin to tell us about the role of these molecules in the regulation of fish immune responses and whether they are similar or divergent to the well-characterised functions of mammalian cytokines. This knowledge will aid our ability to determine and modulate the pathways leading to protective immunity, to improve fish health in aquaculture.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2079-7737
2079-7737
DOI:10.3390/biology5020023