Dopamine-Melanin Colloidal Nanospheres: An Efficient Near-Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy

• Published in: Advanced materials (Weinheim) Vol. 25; no. 9; pp. 1353 - 1359
• Main Authors: Liu, Yanlan, Ai, Kelong, Liu, Jianhua, Deng, Mo, He, Yangyang, Lu, Lehui
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 06.03.2013; WILEY‐VCH Verlag
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biocompatibility; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemical compounds; Colloids; Colloids - chemistry; Colloids - pharmacology; Damage; Density; Dopamine - chemistry; Dopamine - pharmacology; dopamine-melanin; Dose-Response Relationship, Drug; HeLa Cells; Humans; Lasers; Mammary Neoplasms, Experimental - drug therapy; Mammary Neoplasms, Experimental - pathology; Melanins - chemistry; Melanins - pharmacology; Mice; Mice, Inbred BALB C; nanomaterials; Nanospheres; Nanospheres - chemistry; Particle Size; Pharmacology; Phototherapy; photothermal therapy; polymers; Structure-Activity Relationship; Surface Properties; Surgical implants; Temperature; Time Factors; Xenograft Model Antitumor Assays
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.201204683

A new generation of photothermal therapeutic agents based on biopolymer dopamine‐melanin colloidal nanospheres is described. Benefitting from their naturally wide distribution in humans, dopamine‐melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and provide up to 40% photothermal conversion efficiency. After administration, they can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues.