Nucleosides analogues recognition by molecularly imprinted polymer-coated Love wave sensor

• Published in: Micro & nano letters Vol. 8; no. 10; pp. 563 - 566
• Main Authors: Lebal, N, Hallil, H, Dejous, C, Plano, B, Krstulja, A, Delepée, R, Agrofoglio, L, Rebière, D
• Format: Journal Article
• Language: English
• Published: Stevenage The Institution of Engineering and Technology 01.10.2013; John Wiley & Sons, Inc; Institution of Engineering and Technology
• Subjects: acoustic devices; Acoustic propagation; acoustic sensor; acoustic wave propagation; Adenosine monophosphate; AMP concentration; AMP rebinding; AMP‐based MIP layers; aqueous media; biomedical equipment; coatings; Deposition; Engineering Sciences; Extraction; Love waves; Micro and nanotechnologies; Microelectronics; MIP film; molecularly imprinted polymer‐coated Love wave sensor; Nucleosides; Nucleotides; polymer films; porous layers; porous materials; rebinding capacity; Sensors; Special Section: Expanded Papers from NEMS 2013; thin film sensors; Thin films; AMP rebinding; Love waves; AMP concentration; biomedical equipment; MIP film; polymer films; AMP-based MIP layers; aqueous media; acoustic propagation; acoustic devices; acoustic wave propagation; thin film sensors; acoustic sensor; adenosine monophosphate; porous layers; coatings; molecularly imprinted polymer-coated Love wave sensor; rebinding capacity; porous materials; nucleotides; AMP detection; thin film molecularly imprinted polymer; cancer biomarkers; Love wave sensor
• ISSN: 1750-0443; 1750-0443
• DOI: 10.1049/mnl.2013.0207

Presented is a process for thin film molecularly imprinted polymer (MIP) coating based on commercial nucleotides adenosine monophosphate (AMP). The compatibility of the MIP film with acoustic propagation and sensor sensitivity for rebinding of AMP have been verified. Thin and porous layers of AMP-based MIP layers were successfully deposited on the sensor surface. Detection tests of AMP have been performed in aqueous media. The sensor response was recorded in terms of frequency and total insertion losses after both steps: AMP extraction from MIP then AMP rebinding. The sensor showed high sensitivity to 25 ppm AMP concentration. The effect of the extraction time on rebinding capacity of the MIP layer has been proven.