Application of ultrasound imaging biomarkers (HistoScanning™) improves staging reliability of prostate biopsies

• Published in: BMC research notes Vol. 10; no. 1; p. 579
• Main Authors: Hamann, M F, Meyer, D, Knüpfer, S, Fuchs, J, Jünemann, K P, Naumann, C M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.11.2017; BioMed Central; BMC
• Subjects: Biological markers; Biopsy; Diagnosis; HistoScanning; Imaging biomarkers; Prostate biopsy; Prostate cancer; Research Note; Ultrasound; Ultrasound imaging; Prostate biopsy; Imaging biomarkers; Prostate cancer; Ultrasound; HistoScanning
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-017-2896-y

Imaging biomarkers like HistoScanning™ augment the informative value of ultrasound. Analogue image-guidance might improve the diagnostic accuracy of prostate biopsies and reduce misclassifications in preoperative staging and grading. Comparison of 77 image-guided versus 88 systematic prostate biopsies revealed that incorrect staging and Gleason misclassification occurs less frequently in image-guided than in systematic prostate biopsies. Systematic prostate biopsies (4-36 cores, median 12 cores) tended to detect predominantly unilateral tumors (39% sensitivity, 90.9% specificity, 17.5% negative and 50% positive predictive values). Bilateral tumors were diagnosed more frequently by image-guided prostate biopsies (87.9% sensitivity, 72.7% specificity, 50% negative and 96.8% positive predictive values). Regarding the detection of lesions with high Gleason scores ≥ 3 + 4, systematic prostate and image-guided biopsies yielded sensitivity and specificity rates of 66.7% vs 93.5%, 86% vs 64.5%, as well as negative and positive predictive values of 71.2% vs 87%, and 83.3% vs 79.6%, respectively. Potential reason for systematic prostate biopsies missing the correct laterality and the correct Gleason score was a mismatch between the biopsy template and the respective pathological cancer localization. This supports the need for improved detection techniques such as ultrasound imaging biomarkers and image-adapted biopsies.