NLRP3: A promising therapeutic target for autoimmune diseases

NLRP3, a member of nucleotide-binding domain-(NOD) like receptor family, can be found in large varieties of immune and non-immune cells. Upon activation, the NLRP3, apoptosis-associated speck-like protein (ASC) and pro-caspase-1 would assemble into a multimeric protein, called the NLRP3 inflammasome...

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Published inAutoimmunity reviews Vol. 17; no. 7; pp. 694 - 702
Main Authors Shen, Hui-Hui, Yang, Yue-Xin, Meng, Xiang, Luo, Xiao-Yun, Li, Xiao-Mei, Shuai, Zong-Wen, Ye, Dong-Qing, Pan, Hai-Feng
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2018
Subjects
Autoimmune disease
Autoimmunity
Inflammasomes
NLRP3
Autoimmunity
NOD
SSc
Inflammasomes
PRRs
Treg
Autoimmune disease
IBD
NACTH
SLE
LRR
DAMPs
CARD
RA
ASC
ROS
SNPs
NLRP3
PAMPs
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Summary:NLRP3, a member of nucleotide-binding domain-(NOD) like receptor family, can be found in large varieties of immune and non-immune cells. Upon activation, the NLRP3, apoptosis-associated speck-like protein (ASC) and pro-caspase-1 would assemble into a multimeric protein, called the NLRP3 inflammasome. Then the inflammasome promotes inflammation (through specific cleavage and production of bioactive IL-1β and IL-18) and pyroptotic cell death. Previous studies have indicated the importance of NLRP3 in regulating innate immunity. Recently, numerous studies have revealed their significance in autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc) and inflammatory bowel disease (IBD). In this review, we will briefly discuss the biological features of NLRP3 and summarize the recent progression of the involvement of NLRP3 in the development and pathogenesis of autoimmune diseases, as well as its clinical implications and therapeutic potential.
ISSN:1568-9972
1568-9972
1873-0183
DOI:10.1016/j.autrev.2018.01.020